The current trend on many knowledge areas is focused on miniaturization, automatization and simplification of analytical and bioanalytical systems.

The miniaturization of the analytical systems intends the size reduction of these devices, including in those different steps such as pretreatment (filtration, extraction, etc….), mixing, reaction, preconcentration, separation and detection. This has produced the called Lab-on-a-Chip (LOC) or micro-Total Analysis Systems (μTAS).

The main advantages of these miniaturized systems are: miniaturization and portability, automatization, low cost, negligible consumption of reagents/sample and waste generation, which allows to realize medical diagnoses using a drop of blood as well as development of sensors “in-vivo”. Besides, the analysis time is shorter and parallel assays could be performed.

Among different microsystems, microchips electrophoresis (ME) have demonstrated to be a powerful tool.

Additional instrumentation is required in order to work with these devices: high-voltage power supplies, a detection system and a holder.

Complements and instrumentation should be easily miniaturized in order to get a real portable and robust system based on microchip capillary electrophoresis.

Nowadays, most of the electronic elements can be miniaturized. Nevertheless, the optical elements of different detection systems are not easily miniaturized without decreasing the performance. In this point, the electrochemical detection systems are easily miniaturized without decreasing the sensitivity and even improving the signal/noise ratio.